The next generation of radioimmunotherapy: Targeted alpha therapy (TAT)

Nanoparticle Formulations of siRNA: The Next Generation of Targeted Therapy for Lymphomas and Leukemias?

Many liquid tumors (lymphomas and leukemias) have characteristic genomic alterations that are critical to their disease development and progression. For example, greater than 90% of the chronic myelogenous leukemias (CML) are caused by the t(9;22)(q34;q11) or BCR/ABL translocation, whereas more than 75% of mantle cell lymphomas have the t(11,14)(q13, 32) translocation (Kurzrock et al., 2003; Li...

Practice guidelines for Targeted Next Generation Sequencing

DNA sequencing is the most commonly used approach for mutation scanning and is widely regarded as the gold standard. Agreed practice guidelines for both the sequencing process and data analysis are important to achieve a high quality approach, with common quality standards across different laboratories. These guidelines do not constitute an experimental protocol or troubleshooting guide, rather...

Targeted Next-Generation Sequencing for Forensic Genomics

Next-Generation Sequencing: Targeting Targeted Therapies.

Next-generation sequencing (NGS) has given new perspective in oncology. With the ongoing development of targeted therapies, NGS is evolving molecular diagnostics by providing comprehensive interrogation of clinically actionable genomic aberrations in tumors. Having this assay as the primary testing method produces clinically beneficial results. See related article by Drilon et al., p. 3631.

Bio-Informatics - Next Generation Cancer Targeted Therapies

Since its birth in the 1980s, bio-informatics has been rapidly growing, keeping pace with the expansion of genome sequence data. Latest technological development of large-scale gene expression analysis using DNA micro-arrays and proteomics experiments has further boosted the importance of bio-informatics methods. In Bio-Informatics a lot of tools & algorithms are developed to study detailed sha...